Formulation and Characterization of Herbal Cleansing Gel from Turmeric Extract Loaded Nanostructured Lipid Carriers
DOI:
https://doi.org/10.11113/bioprocessing.v2n1.25Keywords:
Herbal cleansing gel, Nanostructured lipid carriers (NLCs), Turmeric extract loaded nanostructured lipid carriersAbstract
The herbal cleansing gel from turmeric extract is a natural skin care product with antioxidant, antimicrobial, and anti-inflammatory properties. Despite its advantages, turmeric extract has a higher metabolism, a low absorption rate, stability, and solubility. Encapsulation of turmeric extract had been developed to increase the bioavailability of turmeric extract for topical drug delivery. Hence, turmeric extract is encapsulated via nanostructured lipid carriers (NLCs) to produce turmeric extract-loaded nanostructured lipid carriers (T-NLCs). This project highlights the formulation and characterization of an herbal cleansing gel from encapsulated turmeric extract. To produce T-NLCs, medium-chain triglycerides (MCT) as liquid lipid and glycerol monostearate (GMS) as solid lipid generated an imperfect matrix incorporating turmeric extract. The T-NLCs were then characterized in terms of particle size, polydispersity index, zeta potential, encapsulation efficiency, and stability. The T-NLCs exhibited particle size 129.407 ± 1.278 nm, polydispersity index 15.067 ± 2.105%, zeta potential -44.7 ± 1.8 mV, encapsulation efficiency 98.04 ± 9.19 % and remained stable over 30 days. The herbal cleansing gel was formulated with T-NLCs and characterized in term sensory test. The formulation is believed to improve the turmeric extract's phytochemical stability, biocompatibility, skin permeability, and dermo-cosmetic efficiency. In conclusion, developing turmeric in an innovative encapsulated formulation has aided in developing herbal-based cosmetic products for a wide range of skin care systems.
References
Abbas, S., Latif, S., Muhamad, I., Hesan, M., & Kormin, F. (2022). In vitro antioxidant and anticholinesterase activities of ethanolic turmeric crude extract. Food Research. 6(4), 199-204.
Abd El‐Hack, M. E., El‐Saadony, M. T., Swelum, A. A., Arif, M., Abo Ghanima, M. M., Shukry, M., . . . El‐Tarabily, K. A. (2021). Curcumin, the active substance of turmeric: its effects on health and ways to improve its bioavailability. Journal of the Science of Food and Agriculture. 101(14), 5747-5762.
Bhadra, P. (2020). A Literature Review Onacne Due to Hormonal Changes and Lifestyle. Indian Journal of Natural Sciences. 10(59), 18507-18521.
Danaei, M., Dehghankhold, M., Ataei, S., Hasanzadeh Davarani, F., Javanmard, R., Dokhani, A., . . . Mozafari, M. (2018). Impact of particle size and polydispersity index on the clinical applications of lipidic nanocarrier systems. Pharmaceutics. 10(2), 57.
Effiom, O. E., & Abaye, D. S. (2020). Antimicrobial Activity of Ginger (Zingiber Officinale Rosc oe) and Turmeric (Curcuma Louga) Extracts Against Propionibacterium Acnes Isolates from Human Pimples, Abuja, Nigeria. GSJ, 8(9).
Fathima, N., & Hiremath, S. G. (2022). Cosmetics as Gara visha: A review. International Journal of Multidisciplinary Research and Growth Evaluation. 3(6), 483-486.
Gonçalves, C., Ramalho, M. J., Silva, R., Silva, V., Marques-Oliveira, R., Silva, A. C., . . . Loureiro, J. A. (2021). Lipid Nanoparticles Containing Mixtures of Antioxidants to Improve Skin Care and Cancer Prevention. Pharmaceutics. 13(12), 2042.
Gopinath, H., & Karthikeyan, K. (2018). Turmeric: a condiment, cosmetic and cure. Indian Journal of Dermatology, Venereology & Leprology. 84(1).
Hadi, A. A., Ng, J. Y., Shamsuddin, M., Matmin, J., & Malek, N. A. N. N. (2022). Green synthesis of silver nanoparticles using Diplazium esculentum extract: catalytic reduction of methylene blue and antibacterial activities. Chemical Papers. 76(1), 65-77.
Hu, C., Qian, A., Wang, Q., Xu, F., He, Y., Xu, J., . . . Xia, Q. (2016). Industrialization of lipid nanoparticles: From laboratory-scale to large-scale production line. European Journal of Pharmaceutics and Biopharmaceutics. 109, 206-213.
Khatun, M., Nur, M. A., Biswas, S., Khan, M., & Amin, M. Z. (2021). Assessment of the anti-oxidant, anti-inflammatory and anti-bacterial activities of different types of turmeric (Curcuma longa) powder in Bangladesh. Journal of Agriculture and Food Research. 6, 100201.
Kim, L., & Lio, P. (2020). Turmeric, curcumin, and curcuminoids: a dermatologic review. Clinical Focus. October 2020, 38-42.
Makoni, P. A., Wa Kasongo, K., & Walker, R. B. (2019). Short term stability testing of efavirenz-loaded solid lipid nanoparticle (SLN) and nanostructured lipid carrier (NLC) dispersions. Pharmaceutics. 11(8), 397.
Mijaljica, D., Spada, F., & Harrison, I. P. (2022). Skin cleansing without or with compromise: soaps and syndets. Molecules. 27(6), 2010.
Park, S. J., Garcia, C. V., Shin, G. H., & Kim, J. T. (2018). Improvement of curcuminoid bioaccessibility from turmeric by a nanostructured lipid carrier system. Food Chemistry. 251, 51-57.
Rapalli, V. K., Kaul, V., Waghule, T., Gorantla, S., Sharma, S., Roy, A., . . . Singhvi, G. (2020). Curcumin loaded nanostructured lipid carriers for enhanced skin retained topical delivery: optimization, scale-up, in-vitro characterization and assessment of ex-vivo skin deposition. European Journal of Pharmaceutical Sciences. 152, 105438.
Rubin, C. B., & Brod, B. (2019). Natural does not mean safe—the dirt on clean beauty products. JAMA Dermatology, 155(12), 1344-1345.
Suryawati, N., & Jawi, I. M. (2020). Potential development of turmeric extract nanoparticles as a topical anti-inflammatory agent. Bali Medical Journal. 9(3), 573-578.
